Autoantibodies to Epilepsy-Related LGI1 in Limbic Encephalitis Neutralize LGI1-ADAM22 Interaction and Reduce Synaptic AMPA Receptors

More than 30 mutations in LGI1, a secreted neuronal protein, have been reported with autosomal dominant lateral temporal lobe epilepsy (ADLTE). Although LGI1 haploinsufficiency is thought to cause ADLTE, the underlying molecular mechanism that results in abnormal brain excitability remains mysteriou...

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Detalhes bibliográficos
Main Authors: Ohkawa, Toshika, Fukata, Yuko, Yamasaki, Miwako, Miyazaki, Taisuke, Yokoi, Norihiko, Takashima, Hiroshi, Watanabe, Masahiko, Watanabe, Osamu, Fukata, Masaki
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828467/
https://ncbi.nlm.nih.gov/pubmed/24227725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3506-13.2013
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