Autoantibodies to Epilepsy-Related LGI1 in Limbic Encephalitis Neutralize LGI1-ADAM22 Interaction and Reduce Synaptic AMPA Receptors

More than 30 mutations in LGI1, a secreted neuronal protein, have been reported with autosomal dominant lateral temporal lobe epilepsy (ADLTE). Although LGI1 haploinsufficiency is thought to cause ADLTE, the underlying molecular mechanism that results in abnormal brain excitability remains mysteriou...

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Hauptverfasser: Ohkawa, Toshika, Fukata, Yuko, Yamasaki, Miwako, Miyazaki, Taisuke, Yokoi, Norihiko, Takashima, Hiroshi, Watanabe, Masahiko, Watanabe, Osamu, Fukata, Masaki
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828467/
https://ncbi.nlm.nih.gov/pubmed/24227725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3506-13.2013
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