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Probing of G-Quadruplex Structures via Ligand-Sensitized Photochemical Reactions in (Br)U-Substituted DNA
We studied photochemical reactions of (Br)U-substituted G-quadruplex (G4) DNA substrates with two pyrene-substituted polyazamacrocyclic ligands, M-1PY and M-2PY. Both ligands bind to and stabilize G4-DNA structures without altering their folding topology, as demonstrated by FRET-melting experiments,...
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| Publicado en: | Sci Rep |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6202380/ https://ncbi.nlm.nih.gov/pubmed/30361545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34141-z |
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