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Epitope Specific Affinity Maturation Improved Stability of Potent Protease Inhibitory Antibodies
Targeting effectual epitopes is essential for therapeutic antibodies to accomplish their desired biological functions. This study developed a competitive dual color FACS to maturate a matrix-metalloprotease 14 (MMP-14) inhibitory antibody. Epitope specific screening was achieved by selection on MMP-...
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| Publicado no: | Biotechnol Bioeng |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6202216/ https://ncbi.nlm.nih.gov/pubmed/30102763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26814 |
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