Epitope Specific Affinity Maturation Improved Stability of Potent Protease Inhibitory Antibodies

Targeting effectual epitopes is essential for therapeutic antibodies to accomplish their desired biological functions. This study developed a competitive dual color FACS to maturate a matrix-metalloprotease 14 (MMP-14) inhibitory antibody. Epitope specific screening was achieved by selection on MMP-...

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Bibliographic Details
Published in:Biotechnol Bioeng
Main Authors: Lopez, Tyler, Chuan, Chen, Ramirez, Aaron, Chen, Kuan-Hui E., Lorenson, Mary Y., Benitez, Chris, Mustafa, Zahid, Pham, Henry, Sanchez, Ramon, Walker, Ameae M., Ge, Xin
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202216/
https://ncbi.nlm.nih.gov/pubmed/30102763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26814
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