A CRISPR screen identifies IFI6 as an ER-resident interferon effector that blocks flavivirus replication

The endoplasmic reticulum (ER) is an architecturally diverse organelle that serves as a membrane source for the replication of multiple viruses. Flaviviruses, including yellow fever virus, West Nile virus, dengue virus and Zika virus, induce unique single-membrane ER invaginations that house the vir...

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Bibliografiske detaljer
Udgivet i:Nat Microbiol
Main Authors: Richardson, R. Blake, Ohlson, Maikke B., Eitson, Jennifer L., Kumar, Ashwani, McDougal, Matthew B., Boys, Ian N., Mar, Katrina B., De La Cruz-Rivera, Pamela C., Douglas, Connor, Konopka, Genevieve, Xing, Chao, Schoggins, John W.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Letter
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202210/
https://ncbi.nlm.nih.gov/pubmed/30224801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-018-0244-1
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