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Leishmania parasitophorous vacuole membranes display phosphoinositides that create conditions for continuous Akt activation and a target for miltefosine in Leishmania infections
Miltefosine is an important drug for the treatment of leishmaniasis; however, its mechanism of action is still poorly understood. In these studies, we tested the hypothesis that like in cancer cells, miltefosine’s efficacy in leishmaniasis is due to its inhibition of Akt activation in host cells. We...
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| Publicado no: | Cell Microbiol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6202129/ https://ncbi.nlm.nih.gov/pubmed/29993167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cmi.12889 |
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