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Leishmania parasitophorous vacuole membranes display phosphoinositides that create conditions for continuous Akt activation and a target for miltefosine in Leishmania infections
Miltefosine is an important drug for the treatment of leishmaniasis; however, its mechanism of action is still poorly understood. In these studies, we tested the hypothesis that like in cancer cells, miltefosine’s efficacy in leishmaniasis is due to its inhibition of Akt activation in host cells. We...
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| Publicat a: | Cell Microbiol |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6202129/ https://ncbi.nlm.nih.gov/pubmed/29993167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cmi.12889 |
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