The DWORF micropeptide enhances contractility and prevents heart failure in a mouse model of dilated cardiomyopathy

Calcium (Ca(2+)) dysregulation is a hallmark of heart failure and is characterized by impaired Ca(2+) sequestration into the sarcoplasmic reticulum (SR) by the SR-Ca(2+)-ATPase (SERCA). We recently discovered a micropeptide named DWORF (DWarf Open Reading Frame) that enhances SERCA activity by displ...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Makarewich, Catherine A, Munir, Amir Z, Schiattarella, Gabriele G, Bezprozvannaya, Svetlana, Raguimova, Olga N, Cho, Ellen E, Vidal, Alexander H, Robia, Seth L, Bassel-Duby, Rhonda, Olson, Eric N
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202051/
https://ncbi.nlm.nih.gov/pubmed/30299255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38319
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