Andrographolide enhances the anti-metastatic effect of radiation in Ras-transformed cells via suppression of ERK–mediated MMP-2 activity

BACKGROUND: Activation of Ras oncogene in human tumors is associated with radiation-associated metastatic potential. Although ionizing radiation is one important method of cancer treatments, it has been shown to enhance matrix metalloproteinases (MMPs) activity and facilitates a more aggressive canc...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Yu, Chih-Chia, Chen, Chien-An, Fu, Shu-Ling, Lin, Hon-Yi, Lee, Moon-Sing, Chiou, Wen-Yen, Su, Yu-Chieh, Hung, Shih-Kai
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201887/
https://ncbi.nlm.nih.gov/pubmed/30359388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0205666
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