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Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross‐seeding behavior
Several studies have proposed that fibrillary aggregates of tau and other amyloidogenic proteins are neurotoxic and result in numerous neurodegenerative diseases. However, these studies usually involve sonication or extrusion through needles before experimentation. As a consequence, these methods ma...
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| Publicado no: | Protein Sci |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6201727/ https://ncbi.nlm.nih.gov/pubmed/30125425 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3499 |
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