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Enhanced trypsin thermostability in Pichia pastoris through truncating the flexible region

BACKGROUND: High thermostability is required for trypsin to have wider industrial applications. Target mutagenesis at flexible regions has been proved to be an efficient protein engineering method to enhance the protein thermostability. RESULTS: The flexible regions in porcine trypsin were predicted...

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Detalhes bibliográficos
Publicado no:Microb Cell Fact
Main Authors: Liu, Lin, Yu, Haoran, Du, Kun, Wang, Zhiyan, Gan, Yiru, Huang, He
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201580/
https://ncbi.nlm.nih.gov/pubmed/30359279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-018-1012-x
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