Soluble CD74 Reroutes MIF/CXCR4/AKT‐Mediated Survival of Cardiac Myofibroblasts to Necroptosis

BACKGROUND: Although macrophage migration inhibitory factor (MIF) has been demonstrated to mediate cardioprotection in ischemia/reperfusion injury and antagonize fibrotic effects through its receptor, CD74, the function of the soluble CD74 receptor ectodomain (sCD74) and its interaction with circula...

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Bibliografske podrobnosti
izdano v:J Am Heart Assoc
Main Authors: Soppert, Josefin, Kraemer, Sandra, Beckers, Christian, Averdunk, Luisa, Möllmann, Julia, Denecke, Bernd, Goetzenich, Andreas, Marx, Gernot, Bernhagen, Jürgen, Stoppe, Christian
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201423/
https://ncbi.nlm.nih.gov/pubmed/30371153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.009384
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