Optimized Background Regimen for Treatment of Active Tuberculosis with the Next-Generation Benzothiazinone Macozinone (PBTZ169)

The efficacy of the standardized four-drug regimen (comprising isoniazid, rifampin, pyrazinamide, and ethambutol) for the treatment of tuberculosis (TB) is menaced by the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis. Intensive effo...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Lupien, Andréanne, Vocat, Anthony, Foo, Caroline Shi-Yan, Blattes, Emilyne, Gillon, Jean-Yves, Makarov, Vadim, Cole, Stewart T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Susceptibility
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201121/
https://ncbi.nlm.nih.gov/pubmed/30126954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00840-18
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