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Apoptotic β-cells induce macrophage reprogramming under diabetic conditions

Type 2 diabetes mellitus (T2DM) occurs when insulin-producing pancreatic β-cells fail to secrete sufficient insulin to compensate for insulin resistance. As T2DM progresses, apoptotic β-cells need to be removed by macrophages through efferocytosis that is anti-inflammatory by nature. Paradoxically,...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ward, Meliza G., Li, Ge, Hao, Mingming
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200952/
https://ncbi.nlm.nih.gov/pubmed/30213857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004565
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