Evidence for an Adaptation of a Phage-Derived Holin/Endolysin System to Toxin Transport in Clostridioides difficile

The pathogenicity locus (PaLoc) of Clostridioides difficile usually comprises five genes (tcdR, tcdB, tcdE, tcdA, tcdC). While the proteins TcdA and TcdB represent the main toxins of this pathogen, TcdR and TcdC are involved in the regulation of their production. TcdE is a holin family protein, memb...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Mehner-Breitfeld, Denise, Rathmann, Claudia, Riedel, Thomas, Just, Ingo, Gerhard, Ralf, Overmann, Jörg, Brüser, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200909/
https://ncbi.nlm.nih.gov/pubmed/30405545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.02446
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