Stabilized coronavirus spikes are resistant to conformational changes induced by receptor recognition or proteolysis

Severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 as a highly transmissible pathogenic human betacoronavirus. The viral spike glycoprotein (S) utilizes angiotensin-converting enzyme 2 (ACE2) as a host protein receptor and mediates fusion of the viral and host membranes, making...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Kirchdoerfer, Robert N., Wang, Nianshuang, Pallesen, Jesper, Wrapp, Daniel, Turner, Hannah L., Cottrell, Christopher A., Corbett, Kizzmekia S., Graham, Barney S., McLellan, Jason S., Ward, Andrew B.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200764/
https://ncbi.nlm.nih.gov/pubmed/30356097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34171-7
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