Discovery of a CLN7 model of Batten disease in non-human primates

We have identified a natural Japanese macaque model of the childhood neurodegenerative disorder neuronal ceroid lipofuscinosis, commonly known as Batten Disease, caused by a homozygous frameshift mutation in the CLN7 gene (CLN7(−/−)). Affected macaques display progressive neurological deficits inclu...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: McBride, Jodi L., Neuringer, Martha, Ferguson, Betsy, Kohama, Steven G., Tagge, Ian J., Zweig, Robert C., Renner, Laurie M., McGill, Trevor J., Stoddard, Jonathan, Peterson, Samuel, Su, Weiping, Sherman, Larry S., Domire, Jacqueline S., Ducore, Rebecca M., Colgin, Lois M., Lewis, Anne D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200145/
https://ncbi.nlm.nih.gov/pubmed/30048804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.07.013
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