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Isoflurane disrupts excitatory neurotransmitter dynamics via inhibition of mitochondrial complex I
BACKGROUND: The mechanisms of action of volatile anaesthetics are unclear. Volatile anaesthetics selectively inhibit complex I in the mitochondrial respiratory chain. Mice in which the mitochondrial complex I subunit NDUFS4 is knocked out [Ndufs4(KO)] either globally or in glutamatergic neurons are...
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| 發表在: | Br J Anaesth |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Elsevier
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6200108/ https://ncbi.nlm.nih.gov/pubmed/29661379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2018.01.036 |
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