Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice

BACKGROUND: Perioperative neurocognitive disorders (PND) result in long-term morbidity and mortality with no effective interventions available. Because interleukin-6 (IL-6), a pro-inflammatory cytokine, is consistently up-regulated by trauma, including after surgery, we determined whether IL-6 is a...

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Dettagli Bibliografici
Pubblicato in:Br J Anaesth
Autori principali: Hu, J., Feng, X., Valdearcos, M., Lutrin, D., Uchida, Y., Koliwad, S.K., Maze, M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018
Soggetti:
Neuroscience and Neuroanaesthesia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200097/
https://ncbi.nlm.nih.gov/pubmed/29452810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bja.2017.11.096
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