Comprehensive Validation of Snapback Primer-Based Melting Curve Analysis to Detect Nucleotide Variation in the Codon 12 and 13 of KRAS Gene

BACKGROUND: KRAS genotyping in tumor samples is a decisive clinical test for the anti-EGFR therapy management. However, the complexity of KRAS mutation landscape across different cancer types and the mosaic effect caused by cancer cellularity and heterogeneity make the choice of KRAS genotyping meth...

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Vydáno v:Biomed Res Int
Hlavní autoři: Zhang, Qunfeng, Du, Yiqiao, Zhang, Xinju, Kang, Zhihua, Guan, Ming, Wu, Zhiyuan
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199860/
https://ncbi.nlm.nih.gov/pubmed/30406144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/8727941
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