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Ionic and cellular mechanisms underlying TBX5/PITX2 insufficiency-induced atrial fibrillation: Insights from mathematical models of human atrial cells

Transcription factors TBX5 and PITX2 involve in the regulation of gene expression of ion channels and are closely associated with atrial fibrillation (AF), the most common cardiac arrhythmia in developed countries. The exact cellular and molecular mechanisms underlying the increased susceptibility t...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Bai, Jieyun, Gladding, Patrick A., Stiles, Martin K., Fedorov, Vadim V., Zhao, Jichao
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199257/
https://ncbi.nlm.nih.gov/pubmed/30353147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33958-y
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