PITX2 upregulation increases the risk of chronic atrial fibrillation in a dose-dependent manner by modulating I(Ks) and I(CaL)—insights from human atrial modelling

BACKGROUND: Functional analysis has shown that the paired-like homeodomain transcription factor 2 (PITX2) overexpression associated with atrial fibrillation (AF) leads to the slow delayed rectifier K(+) current (I(Ks)) increase and the L-type Ca(2+) current (I(CaL)) reduction observed in isolated ri...

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Vydáno v:Ann Transl Med
Hlavní autoři: Bai, Jieyun, Lu, Yaosheng, Lo, Andy, Zhao, Jichao, Zhang, Henggui
Médium: Artigo
Jazyk:Inglês
Vydáno: AME Publishing Company 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7154416/
https://ncbi.nlm.nih.gov/pubmed/32309338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/atm.2020.01.90
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