Zileuton suppresses cholangiocarcinoma cell proliferation and migration through inhibition of the Akt signaling pathway

BACKGROUND: Inflammatory lipid mediators play an important role in several cancer types. Leukotrienes (LTs), pro-inflammatory lipid mediators, are involved in chronic inflammation and cancer progression. They are derived from arachidonic acid by 5-lipoxygenase (5-LOX) activity. On the other hand, 15...

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Bibliographische Detailangaben
Veröffentlicht in:Onco Targets Ther
Hauptverfasser: Khophai, Sasikamon, Thanee, Malinee, Techasen, Anchalee, Namwat, Nisana, Klanrit, Poramate, Titapun, Attapol, Jarearnrat, Apiwat, Sa-Ngiamwibool, Prakasit, Loilome, Watcharin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2018
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6198876/
https://ncbi.nlm.nih.gov/pubmed/30410359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S178942
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