Healthy Donor Polyclonal IgMs Diminish B-Lymphocyte Autoreactivity, Enhance Regulatory T-Cell Generation, and Reverse Type 1 Diabetes in NOD Mice

Autoimmune diseases such as type 1 diabetes (T1D) arise from unrestrained activation of effector lymphocytes that destroy target tissues. Many efforts have been made to eliminate these effector lymphocytes, but none has produced a long-term cure. An alternative to depletion therapy is to enhance end...

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Udgivet i:Diabetes
Main Authors: Wilson, Christopher S., Chhabra, Preeti, Marshall, Andrew F., Morr, Caleigh V., Stocks, Blair T., Hoopes, Emilee M., Bonami, Rachel H., Poffenberger, Greg, Brayman, Kenneth L., Moore, Daniel J.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2018
Fag:
Immunology and Transplantation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6198348/
https://ncbi.nlm.nih.gov/pubmed/30131391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0456
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