Inactivation of p66Shc Decreases Afferent Arteriolar K(ATP) Channel Activity and Decreases Renal Damage in Diabetic Dahl SS Rats

Increased expression of adaptor protein p66Shc has been associated with progression of diabetic nephropathy. Afferent arteriolar dilation and glomerular hyperfiltration in diabetes are due to increased K(ATP) channel availability and activity. Hyperglycemia was induced in Dahl salt-sensitive (SS) ra...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Miller, Bradley S., Blumenthal, Shoshana R., Shalygin, Alexey, Wright, Kevin D., Staruschenko, Alexander, Imig, John D., Sorokin, Andrey
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2018
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6198347/
https://ncbi.nlm.nih.gov/pubmed/30131395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0308
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