Triazolo[4,5-d]pyrimidines as Validated General Control Nonderepressible 2 (GCN2) Protein Kinase Inhibitors Reduce Growth of Leukemia Cells

Cellular stress signals activate adaptive signaling pathways of the mammalian integrated stress response (ISR), of which the unfolded protein response (UPR) is a subset. These pathways converge at the phosporylation of eIF2α. Drug-like, potent and selective chemical inhibitors (valid chemical probes...

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Detalhes bibliográficos
Publicado no:Comput Struct Biotechnol J
Main Authors: Lough, Lea, Sherman, Dan, Becerra-Flores, Manuel, Vasudevan, Deepika, Lavinda, Olga, Ni, Eric, Wang, Hong, Ryoo, Hyung Don, Tibes, Raoul, Cardozo, Timothy
Formato: Artigo
Idioma:Inglês
Publicado em: Research Network of Computational and Structural Biotechnology 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197744/
https://ncbi.nlm.nih.gov/pubmed/30364637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2018.09.003
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