Suppression of STAT3 signaling promotes cellular reprogramming into insulin-producing cells induced by defined transcription factors

BACKGROUND: STAT3 has been demonstrated to play a role in maintaining cellular identities in the pancreas, whereas an activating STAT3 mutation has been linked to impaired β-cell function. METHODS: The role of STAT3 in β-cell neogenesis, induced by the exogenous expression of Pdx1, Neurog3, and Mafa...

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Spremljeno u:
Bibliografski detalji
Izdano u:EBioMedicine
Glavni autori: Miura, Masaki, Miyatsuka, Takeshi, Katahira, Takehiro, Sasaki, Shugo, Suzuki, Luka, Himuro, Miwa, Nishida, Yuya, Fujitani, Yoshio, Matsuoka, Taka-aki, Watada, Hirotaka
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2018
Teme:
Research paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197741/
https://ncbi.nlm.nih.gov/pubmed/30266298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.09.035
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