COX-2–PGE(2) Signaling Impairs Intestinal Epithelial Regeneration and Associates with TNF Inhibitor Responsiveness in Ulcerative Colitis

BACKGROUND: Inhibition of tumor necrosis factor-α (TNF) signaling is beneficial in the management of ulcerative colitis (UC), but up to one-third of patients do not have a clinical response of relevance to TNF inhibitors during induction therapy (i.e. primary non-responders [PNRs]). Through producti...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Li, Yuan, Soendergaard, Christoffer, Bergenheim, Fredrik Holmberg, Aronoff, David M., Milne, Ginger, Riis, Lene Buhl, Seidelin, Jakob Benedict, Jensen, Kim B., Nielsen, Ole Haagen
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197735/
https://ncbi.nlm.nih.gov/pubmed/30190207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.08.040
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