Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes

OBJECTIVE: Appropriate glucose levels are essential for survival; thus, the detection and correction of low blood glucose is of paramount importance. Hypoglycemia prompts an integrated response involving reduction in insulin release and secretion of key counter-regulatory hormones glucagon and epine...

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Publicado en:Mol Metab
Main Authors: Chakera, Ali J., Hurst, Paul S., Spyer, Gill, Ogunnowo-Bada, Emmanuel O., Marsh, William J., Riches, Christine H., Yueh, Chen-Yu, Markkula, S. Pauliina, Dalley, Jeffrey W., Cox, Roger D., Macdonald, Ian A., Amiel, Stephanie A., MacLeod, Kenneth M., Heisler, Lora K., Hattersley, Andrew T., Evans, Mark L.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2018
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197723/
https://ncbi.nlm.nih.gov/pubmed/30146176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.08.001
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