A Leishmania infantum genetic marker associated with miltefosine treatment failure for visceral leishmaniasis

BACKGROUND: Miltefosine has been used successfully to treat visceral leishmaniasis (VL) in India, but it was unsuccessful for VL in a clinical trial in Brazil. METHODS: To identify molecular markers that predict VL treatment failure whole genome sequencing of 26 L. infantum isolates, from cured and...

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Pubblicato in:EBioMedicine
Autori principali: Carnielli, Juliana B.T., Crouch, Kathryn, Forrester, Sarah, Silva, Vladimir Costa, Carvalho, Sílvio F.G., Damasceno, Jeziel D., Brown, Elaine, Dickens, Nicholas J., Costa, Dorcas L., Costa, Carlos H.N., Dietze, Reynaldo, Jeffares, Daniel C., Mottram, Jeremy C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018
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Research paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197651/
https://ncbi.nlm.nih.gov/pubmed/30268832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.09.029
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