A Leishmania infantum genetic marker associated with miltefosine treatment failure for visceral leishmaniasis

BACKGROUND: Miltefosine has been used successfully to treat visceral leishmaniasis (VL) in India, but it was unsuccessful for VL in a clinical trial in Brazil. METHODS: To identify molecular markers that predict VL treatment failure whole genome sequencing of 26 L. infantum isolates, from cured and...

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Bibliografski detalji
Izdano u:EBioMedicine
Glavni autori: Carnielli, Juliana B.T., Crouch, Kathryn, Forrester, Sarah, Silva, Vladimir Costa, Carvalho, Sílvio F.G., Damasceno, Jeziel D., Brown, Elaine, Dickens, Nicholas J., Costa, Dorcas L., Costa, Carlos H.N., Dietze, Reynaldo, Jeffares, Daniel C., Mottram, Jeremy C.
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2018
Teme:
Research paper
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197651/
https://ncbi.nlm.nih.gov/pubmed/30268832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.09.029
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