Nigrostriatal pathology with reduced astrocytes in LRRK2 S910/S935 phosphorylation deficient knockin mice

Leucine-rich repeat kinase 2 (LRRK2) is genetically implicated in both familial and sporadic Parkinson's disease (PD). Moreover, LRRK2 has emerged as a compelling therapeutic target for the treatment of PD. Consequently, there is much interest in understanding LRRK2 and its role in PD pathogene...

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Veröffentlicht in:Neurobiol Dis
Hauptverfasser: Zhao, Ye, Keshiya, Shikara, Atashrazm, Farzaneh, Gao, Jianqun, Ittner, Lars M., Alessi, Dario R., Halliday, Glenda M., Fu, Yuhong, Dzamko, Nicolas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Academic Press 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197399/
https://ncbi.nlm.nih.gov/pubmed/30194047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2018.09.003
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