The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

Mutations in leucine-rich repeat kinase 2 (LRRK2) are strongly associated with late-onset autosomal dominant Parkinson's disease. LRRK2 is highly expressed in immune cells and recent work points towards a link between LRRK2 and innate immunity. Here we demonstrate that stimulation of the Toll-L...

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Detalhes bibliográficos
Main Authors: Dzamko, Nicolas, Inesta-Vaquera, Francisco, Zhang, Jiazhen, Xie, Chengsong, Cai, Huaibin, Arthur, Simon, Tan, Li, Choi, Hwanguen, Gray, Nathanael, Cohen, Philip, Pedrioli, Patrick, Clark, Kristopher, Alessi, Dario R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3377608/
https://ncbi.nlm.nih.gov/pubmed/22723946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039132
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