Mitochondrial – nuclear genetic interaction modulates whole body metabolism, adiposity and gene expression in vivo

We hypothesized that changes in the mitochondrial DNA (mtDNA) would significantly influence whole body metabolism, adiposity and gene expression in response to diet. Because it is not feasible to directly test these predictions in humans we used Mitochondrial-Nuclear eXchange mice, which have recipr...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Dunham-Snary, Kimberly J., Sandel, Michael W., Sammy, Melissa J., Westbrook, David G., Xiao, Rui, McMonigle, Ryan J., Ratcliffe, William F., Penn, Arthur, Young, Martin E., Ballinger, Scott W.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197375/
https://ncbi.nlm.nih.gov/pubmed/30232024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.08.036
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