Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis

Axon degeneration occurs in all neurodegenerative diseases, but the molecular pathways regulating axon destruction during neurodegeneration are poorly understood. Sterile Alpha and TIR Motif Containing 1 (Sarm1) is an essential component of the prodegenerative pathway driving axon degeneration after...

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Udgivet i:Hum Mol Genet
Main Authors: Peters, Owen M, Lewis, Elizabeth A, Osterloh, Jeannette M, Weiss, Alexandra, Salameh, Johnny S, Metterville, Jake, Brown, Robert H, Freeman, Marc R
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
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General Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196650/
https://ncbi.nlm.nih.gov/pubmed/30010873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy260
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