A subset of esophageal squamous cell carcinoma patient-derived xenografts respond to cetuximab, which is predicted by high EGFR expression and amplification

BACKGROUND: Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal tumors, but most targeted therapies showed no efficacy in non-selected patients. This study aims at investigating the adaptive cetuximab subset in a cohort of esophageal squamous cell carcinoma (ESCC)...

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Detalhes bibliográficos
Publicado no:J Thorac Dis
Main Authors: Zhu, Hanting, Wang, Chunyu, Wang, Jingjing, Chen, Dawei, Deng, Jiaying, Deng, Jianyun, Fan, Jianhong, Badakhshi, Harun, Huang, Xuesong, Zhang, Likun, Cai, Jie, Guo, Sheng, Qian, Wubin, Nie, Yongzhan, Li, Qixiang, Zhao, Kuaile
Formato: Artigo
Idioma:Inglês
Publicado em: AME Publishing Company 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196161/
https://ncbi.nlm.nih.gov/pubmed/30416780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21037/jtd.2018.09.18
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