A subset of gastric cancers with EGFR amplification and overexpression respond to cetuximab therapy

A preclinical trial identified 4 of 20 (20%) gastric cancer (GC) patient-derived xenografts responded to cetuximab. Genome-wide profiling and additional investigations revealed that high EGFR mRNA expression and immunohistochemistry score (3+) are associated with tumor growth inhibition. Furthermore...

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Detalhes bibliográficos
Main Authors: Zhang, Lianhai, Yang, Jie, Cai, Jie, Song, Xiaoming, Deng, Jianyun, Huang, Xuesong, Chen, Dawei, Yang, Mengmeng, Wery, Jean-Pierre, Li, Shuangxi, Wu, Aiwen, Li, Ziyu, Li, Zhongwu, Liu, Yiqiang, Chen, Yiyou, Li, Qixiang, Ji, Jiafu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3801116/
https://ncbi.nlm.nih.gov/pubmed/24141978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02992
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