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NITRIC OXIDE REVERSES DRUG RESISTANCE BY INHIBITING ATPASE ACTIVITY OF P-GLYCOPROTEIN IN HUMAN MULTI-DRUG RESISTANT CANCER CELLS
BACKGROUND: Development of resistance to chemotherapy drugs is a significant problem in treating human malignancies in the clinic. Overexpression of drug efflux proteins, including P-170 glycoprotein (P-gp), an ATP-dependent efflux protein, is one of the main mechanisms responsible for multi-drug re...
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| Pubblicato in: | Biochim Biophys Acta Gen Subj |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6195836/ https://ncbi.nlm.nih.gov/pubmed/30251669 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2018.08.021 |
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