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Herpes Simplex Virus Shedding Rate: Surrogate Outcome for Genital Herpes Recurrence Frequency and Lesion Rates, and Phase 2 Clinical Trials End Point for Evaluating Efficacy of Antivirals
BACKGROUND: We tested whether genital herpes simplex virus (HSV) shedding is an appropriate surrogate outcome for the clinical outcome of genital herpes lesions in studies of HSV-2 antiviral interventions. METHODS: We analyzed prospective data from natural history studies and clinical trials of anti...
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| Publié dans: | J Infect Dis |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6195656/ https://ncbi.nlm.nih.gov/pubmed/30020484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy372 |
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