Herpes Simplex Virus Shedding Rate: Surrogate Outcome for Genital Herpes Recurrence Frequency and Lesion Rates, and Phase 2 Clinical Trials End Point for Evaluating Efficacy of Antivirals

BACKGROUND: We tested whether genital herpes simplex virus (HSV) shedding is an appropriate surrogate outcome for the clinical outcome of genital herpes lesions in studies of HSV-2 antiviral interventions. METHODS: We analyzed prospective data from natural history studies and clinical trials of anti...

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Vydáno v:J Infect Dis
Hlavní autoři: Agyemang, Elfriede, Magaret, Amalia S, Selke, Stacy, Johnston, Christine, Corey, Larry, Wald, Anna
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6195656/
https://ncbi.nlm.nih.gov/pubmed/30020484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy372
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