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Synergistic and independent action of endogenous microRNAs 122a and 199a for post-transcriptional liver detargeting of gene vectors

In hepatocellular carcinoma (HCC), which usually develops in a cirrhotic liver, treatments preserving normal liver function and viability are vitally important. Here, we utilise the differential expression of miRNAs 122a and 199a between normal hepatocytes and HCC to generate vectors harbouring thei...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Dhungel, Bijay, Ramlogan-Steel, Charmaine A., Steel, Jason C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6195616/
https://ncbi.nlm.nih.gov/pubmed/30341383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-33801-4
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