Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Dimethyl fumarate (DMF) has been applied for decades in the treatment of psoriasis and now also multiple sclerosis. However, the mechanism of action has remained obscure and involves high dose over long time of this small, reactive compound implicating many potential targets. Based on a 1.9 Å resolu...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Andersen, Jacob Lauwring, Gesser, Borbala, Funder, Erik Daa, Nielsen, Christine Juul Fælled, Gotfred-Rasmussen, Helle, Rasmussen, Mads Kirchheiner, Toth, Rachel, Gothelf, Kurt Vesterager, Arthur, J. Simon C., Iversen, Lars, Nissen, Poul
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6195510/
https://ncbi.nlm.nih.gov/pubmed/30341347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06787-w
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados