Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Dimethyl fumarate (DMF) has been applied for decades in the treatment of psoriasis and now also multiple sclerosis. However, the mechanism of action has remained obscure and involves high dose over long time of this small, reactive compound implicating many potential targets. Based on a 1.9 Å resolu...

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Udgivet i:Nat Commun
Main Authors: Andersen, Jacob Lauwring, Gesser, Borbala, Funder, Erik Daa, Nielsen, Christine Juul Fælled, Gotfred-Rasmussen, Helle, Rasmussen, Mads Kirchheiner, Toth, Rachel, Gothelf, Kurt Vesterager, Arthur, J. Simon C., Iversen, Lars, Nissen, Poul
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6195510/
https://ncbi.nlm.nih.gov/pubmed/30341347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06787-w
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