Mini-HA Is Superior to Full Length Hemagglutinin Immunization in Inducing Stem-Specific Antibodies and Protection Against Group 1 Influenza Virus Challenges in Mice

Seasonal influenza vaccines are updated almost annually to match the antigenic drift in influenza hemagglutinin (HA) surface glycoprotein. A new HA stem-based antigen, the so-called “mini-HA,” was recently shown to induce cross-protective antibodies. However, cross-reactive antibodies targeting the...

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Vydáno v:Front Immunol
Hlavní autoři: van der Lubbe, Joan E. M., Verspuij, Johan W. A., Huizingh, Jeroen, Schmit-Tillemans, Sonja P. R., Tolboom, Jeroen T. B. M., Dekking, Liesbeth E. H. A., Kwaks, Ted, Brandenburg, Börries, Meijberg, Wim, Zahn, Roland C., Roozendaal, Ramon, Kuipers, Harmjan
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2018
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6194913/
https://ncbi.nlm.nih.gov/pubmed/30369928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02350
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