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Photoactivation of MDM2 Inhibitors: Controlling Protein–Protein Interaction with Light
[Image: see text] Selectivity remains a major challenge in anticancer therapy, which potentially can be overcome by local activation of a cytotoxic drug. Such triggered activation can be obtained through modification of a drug with a photoremovable protecting group (PPG), and subsequent irradiation...
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| Veröffentlicht in: | J Am Chem Soc |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical
Society
2018
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6194649/ https://ncbi.nlm.nih.gov/pubmed/30284823 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b04870 |
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