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A chemical reporter facilitates the detection and identification of lysine HMGylation on histones

Lysine 3-hydroxyl-3-methylglutarylation (HMG-K) is a newly identified PTM that can occur non-enzymatically in mitochondria. However, the substrate scope of this new PTM remains insufficiently explored, which has greatly hindered the progress in interpreting its regulatory mechanisms and cellular fun...

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Detalles Bibliográficos
Publicado en:Chem Sci
Main Authors: Bao, Xiucong, Xiong, Ying, Li, Xin, Li, Xiang David
Formato: Artigo
Idioma:Inglês
Publicado: Royal Society of Chemistry 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6194501/
https://ncbi.nlm.nih.gov/pubmed/30429988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc02483a
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