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Structural metamorphism and polymorphism in proteins on the brink of thermodynamic stability

The classical view of the structure–function paradigm advanced by Anfinsen in the 1960s is that a protein's function is inextricably linked to its three‐dimensional structure and is encrypted in its amino acid sequence. However, it is now known that a significant fraction of the proteome consis...

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Detalles Bibliográficos
Publicado en:Protein Sci
Main Authors: Kulkarni, Prakash, Solomon, Tsega L., He, Yanan, Chen, Yihong, Bryan, Philip N., Orban, John
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley & Sons, Inc. 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6194243/
https://ncbi.nlm.nih.gov/pubmed/30144197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3458
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