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Cryo-EM structures of human STEAP4 reveal mechanism of iron(III) reduction
Enzymes of the six-transmembrane epithelial antigen of the prostate (STEAP) family reduce Fe(3+) and Cu(2+) ions to facilitate metal-ion uptake by mammalian cells. STEAPs are highly upregulated in several types of cancer, making them potential therapeutic targets. However, the structural basis for S...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6194020/ https://ncbi.nlm.nih.gov/pubmed/30337524 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06817-7 |
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