Lysophosphatidic acid acts on LPA(1) receptor to increase H(2)O(2) during flow‐induced dilation in human adipose arterioles

BACKGROUND AND PURPOSE: NO produces arteriolar flow‐induced dilation (FID) in healthy subjects but is replaced by mitochondria‐derived hydrogen peroxide (mtH(2)O(2)) in patients with coronary artery disease (CAD). Lysophosphatidic acid (LPA) is elevated in patients with risk factors for CAD, but its...

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Bibliografiske detaljer
Udgivet i:Br J Pharmacol
Main Authors: Chabowski, Dawid S, Kadlec, Andrew O, Ait‐Aissa, Karima, Hockenberry, Joseph C, Pearson, Paul J, Beyer, Andreas M, Gutterman, David D
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193883/
https://ncbi.nlm.nih.gov/pubmed/30153326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14492
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