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Pairwise and higher order genetic interactions during the evolution of a tRNA

A central question in genetics and evolution is the extent to which mutations have outcomes that change depending on the genetic context in which they occur1–3. Pairwise interactions between mutations have been systematically mapped within4–18 and between19 genes, and contribute substantially to phe...

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Pubblicato in:Nature
Autori principali: Domingo, Júlia, Diss, Guillaume, Lehner, Ben
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6193533/
https://ncbi.nlm.nih.gov/pubmed/29849145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0170-7
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