Mitochondrial Morphology, Function and Homeostasis Are Impaired by Expression of an N-terminal Calpain Cleavage Fragment of Ataxin-3

Alterations in mitochondrial morphology and function have been linked to neurodegenerative diseases, including Parkinson disease, Alzheimer disease and Huntington disease. Metabolic defects, resulting from dysfunctional mitochondria, have been reported in patients and respective animal models of all...

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Veröffentlicht in:Front Mol Neurosci
Hauptverfasser: Harmuth, Tina, Prell-Schicker, Caroline, Weber, Jonasz J., Gellerich, Frank, Funke, Claudia, Drießen, Stefan, Magg, Janine C. D., Krebiehl, Guido, Wolburg, Hartwig, Hayer, Stefanie N., Hauser, Stefan, Krüger, Rejko, Schöls, Ludger, Riess, Olaf, Hübener-Schmid, Jeannette
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192284/
https://ncbi.nlm.nih.gov/pubmed/30364204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00368
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