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Absence of the Spindle Assembly Checkpoint Restores Mitotic Fidelity upon Loss of Sister Chromatid Cohesion

The fidelity of mitosis depends on cohesive forces that keep sister chromatids together. This is mediated by cohesin that embraces sister chromatid fibers from the time of their replication until the subsequent mitosis [1, 2, 3]. Cleavage of cohesin marks anaphase onset, where single chromatids are...

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Veröffentlicht in:Curr Biol
Hauptverfasser: Silva, Rui D., Mirkovic, Mihailo, Guilgur, Leonardo G., Rathore, Om S., Martinho, Rui Gonçalo, Oliveira, Raquel A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6191932/
https://ncbi.nlm.nih.gov/pubmed/30122528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2018.06.062
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