Human breast tumor-infiltrating CD8(+) T cells retain polyfunctionality despite PD-1 expression

Functional CD8(+) T cells in human tumors play a clear role in clinical prognosis and response to immunotherapeutic interventions. PD-1 expression in T cells involved in chronic infections and tumors such as melanoma often correlates with a state of T-cell exhaustion. Here we interrogate CD8(+) tumo...

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Vydáno v:Nat Commun
Hlavní autoři: Egelston, Colt A., Avalos, Christian, Tu, Travis Y., Simons, Diana L., Jimenez, Grecia, Jung, Jae Y., Melstrom, Laleh, Margolin, Kim, Yim, John H., Kruper, Laura, Mortimer, Joanne, Lee, Peter P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6191461/
https://ncbi.nlm.nih.gov/pubmed/30327458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06653-9
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